COVID-19 Guidance

Familial Breast Cancer

General screening

  • 50y to 70y invited every three years
  • > 70y GP can refer to local screening unit
Who can be managed in primary care.

If the family history shows only one 1st degree or 2nd degree relative diagnosed with breast cancer at > 40y old, provided that none of the following is present in Family history:

  • Bilateral breast cancer
  • Male breast cancer
  • Ovarian cancer
  • Jewish ancestry
  • Sarcoma in a relative younger than age 45y
  • Glioma or childhood adrenal cortical carcinomas
  • Complicated patterns of multiple cancers at a young age
  • Paternal history of breast cancer (two or more relatives on the father’s side of the family)

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When to refer to the breast service (for initial screening)

  • One 1st degree F relative diagnosed with breast cancer at < 40y
  • One 1st degree M relative diagnosed with breast cancer at any age
  • One 1st relative with bilateral breast cancer where the first primary was diagnosed at younger than age < 50y
  • Two 1st degree relatives, or one 1st degree and one 2nd relative, diagnosed with breast cancer at any age
  • One 1st degree or 2nd degree relative diagnosed with breast cancer at any age and one 1st degree or 2nd degree relative diagnosed with ovarian cancer at any age [one of these should be a 1st degree relative]
  • Three 1st degree or 2nd degree relatives diagnosed with breast cancer at any age
  • Breast cancers that do not fit with any of the above, but there is one/more of the following in Family History:
    • Bilateral breast cancer
    • Male breast cancer
    • Ovarian cancer
    • Jewish ancestry
    • Sarcoma in a relative younger than age 45y
    • Glioma or childhood adrenal cortical carcinomas
    • Complicated patterns of multiple cancers at a young age
    • Paternal history of breast cancer (two or more relatives on the father’s side of the family)

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Degrees of relatives

  • 1st  – Relatives share half of their genes with the person – parents, brother, sister,  or child.
  • 2nd – Relatives shares about one quarter of their genes with the person –  uncle, aunt, nephew, niece, grandparent, grandchild or half-sibling.
  • 3rd – Relatives share about one eighth of their genes with the person – first cousin, great-grandparent or great-grandchild.

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