Options
Simvastatin, Atrovastatin, Pravastatin, Rosuvastatin, Fluvastatin
Interaction
· Amlodipine, verapamil, diltiazem – Reduce simvastatin to 20mg [risk of myopathy] or switch to other statin
Primary prevention
· >= 10% 10y risk of CVD
· TC:HDL >= 6 [Normal =< 4]
· Simvastatin 40mg OD – Take one tablet at night – remember have blood check at 3 months ( ) and 12 months ( ) of starting treatment to monitor if impacting liver.
Secondary prevention
· Diabetics > 40y old or establish cardiovascular disease [PAD,CHD, TIA…]
· Simvastatin 40mg OD – Take one tablet at night – remember have blood check at 3 months ( ) and 12 months ( ) of starting treatment to monitor if impacting liver.
· Target – [Reduction of 25% of TC or 30% of LDL] or [TC < 4 or LDL < 2] which ever greater.
· Increase Simvastatin 80mg if target not reached.